Tumor Immune Microenvironment (TIME)

The tumor immune microenvironment (TIME) plays a critical role in regulating tumor progression and the response to chemotherapy. Studies focusing on tumor immune microenvironment (TIME) mainly concerns about the function, phenotype and composition of various tumor infiltrated immune cells, such as T lymphocytes, B lymphocytes, natural killer (NK) cells, tumor-associated macrophages (TAM), dendritic cells (DC), neutrophils , and stromal cells as well. In progressing cancers, neither the tumor nor the TIME is static. Reciprocal interactions between tumor and associated immune and stromal cell types evolve as the tumor grows, thus allowing for modulation of both tumor cell intrinsic and extrinsic processes. At the same time, oncogene-driven expression of cytokines critical for the recruitment and phenotype of immune cells, with potent effects to build an immunosuppressive TIME. 

Featured Research Tools of Tumor-infiltrated Immune Cell Characterization (including immunocheckpoints)
Target:
CD3D ; CD3E; CD3E/G ;CD4;CD8;CD11a;CD11b;CD19;CD20;CD23;CD27;CD28; CD38 ; CD40; CD45 ; CD46 ;CD47 ; CD49b ; CD49d ;CD49e ; CD54 ; CD55 ; CD61 ; CD62P ; CD63 ; CD66a ; CD66e

​Tumor Immune Microenvironment Related Publication:

• Remodeling “cold” tumor immune microenvironment via epigenetic-based therapy using targeted liposomes with in situ formed albumin corona. ncbi: 35847495
• Regulation of Tumor Growth and Metastasis: The Role of Tumor Microenvironment. sage:https://doi.org/10.4137/CGM.S1128
• Role of the Tumor Microenvironment in Breast Cancer. karger:doi.org/10.1159/000430499
• Role of tumor microenvironment in tumorigenesis. ncbi: 28382138